LIVIA — Local Interaction Visualization and Analysis

Prediction Analysis

Upload prediction files from AlphaFold3, ColabFold, Boltz, Chai-1, or OpenFold. Calculate interface confidence metrics (iLIS, LIS, cLIS), view interactive PAE/LIS/cLIS maps, and generate visualization scripts.

Launch Prediction Analysis →

Supports any major structure prediction platform — no installation needed.

Browse Precomputed Interactomes — FlyPredictome · AlphaFold DB

FlyPredictome

Search Drosophila protein interactions from FlyPredictome predictions.

e.g., Akt1–foxo, Dl–N, Dsh–Axn

Ortholog Interactome

Search human kinase–TF interactions from ortholog predictions (Kim et al. 2025).

e.g., TP53, CDK2, AKT1, BRAF

AFDB Dimer

Fetch dimer predictions from the AlphaFold Protein Structure Database.

e.g., Fiber protein 2, pp71

AFDB Monomer Subdomain alpha

Analyze intramolecular domain interactions in AlphaFold monomer predictions.

e.g., Haspin (Q8TF76), SCN9A (Q15858)

Tutorials

Visual walkthroughs for each tool — learn by example.

About

Metric definitions, color schemes, and references.

GitHub

Source code, documentation, and issue tracker.

Browser: Tested on Chrome and Safari (macOS/iOS). All analysis runs locally in your browser — no data leaves your device.
Note: Each prediction platform (AlphaFold3, ColabFold, Boltz, Chai-1, etc.) may produce different confidence calibrations. The iLIS ≥ 0.223 threshold was established using ColabFold/AlphaFold-Multimer predictions. Other platforms may require adjusted thresholds.

LIVIA — Local Interaction VIsualization and Analysis